AgroupoffiveyoungfriendstravelfromLosAngelestoexoticPanamaforaweekofpartyinginlushtropicalparadise.Befriendingabeautifullocalwomanintheirhotelbar,theylearnofasecretjunglehiketoapristinewaterfallnearby.Thewomancautionsthemstronglyagainstthehike,warningthatothergringosinsearchofthelegendarywaterfallhadmysteriouslydisappearedintothejungle,nevertobeseenorheardfromagain.
　　Ignoringherwarnings,thegroupconvincesthewomantoguidethemtothepicturesquewaterfall,thinkingthattheyhavenothingtofearwithalocalastheirguide.Whatbeginsasafunoutingquicklyturnsterrifyingwhentheirguidemysteriouslyvanishesafteraromantictrystatthefalls.Asnightclosesin,thefriendsrealizetoolatethetruthbehindherwarnings—horrific,bloodthirsty,flesh-eatingcreaturesarenowstalkingthem.Themangledsurvivorsrushtojunglecavesforshelter,onlytorealizethey’veenteredthemonsters’lair!